(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

Base Information

Chemical Name:(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol
CAS No.:1198785-24-8
Molecular Formula:C₁₅H₂₀ClF₃O₄S
Molecular Weight:388.836
Hs Code.:

Synonyms:(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

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Technology Process of (R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

There total 2 articles about (R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (R)-5-(4-chloro-2-methylsulfonylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

: 1198785-24-8
(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

Guidance literature:: (R)-5-(4-chloro-2-methylsulfonylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 1198785-22-6
5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

: 1198785-24-8
(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / ruthenium trichloride / water; acetonitrile / 18 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With sodium periodate; lithium aluminium tetrahydride; ruthenium trichloride; In tetrahydrofuran; water; acetonitrile;