(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

Base Information

Chemical Name:(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol
CAS No.:1198785-26-0
Molecular Formula:C₁₆H₁₈ClF₃O₃S
Molecular Weight:382.831
Hs Code.:

Synonyms:(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

Suppliers and Price of (S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

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Technology Process of (S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

There total 3 articles about (S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1198785-25-9
(R)-5-(4-chloro-2-methanesulfonylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanal

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 1198785-26-0
(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;

Reference yield:

: 1198785-22-6
5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

: 1198785-26-0
(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate / ruthenium trichloride / water; acetonitrile / 18 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 20 - 50 °C

4: potassium carbonate / methanol / 20 °C

With sodium periodate; lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; ruthenium trichloride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1198785-24-8
(R)-5-(4-chloro-2-methanesulfonylphenyl)-5-methyl-3-trifluoromethylhexane-1,3-diol

: 1198785-26-0
(S)-6-(4-chloro-2-methanesulfonylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 20 - 50 °C

2: potassium carbonate / methanol / 20 °C

With potassium carbonate; Dess-Martin periodane; In methanol; dichloromethane;