5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

Base Information

Chemical Name:5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester
CAS No.:1198785-22-6
Molecular Formula:C₃₁H₃₃ClF₃NO₅S₂
Molecular Weight:656.187
Hs Code.:

Synonyms:5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

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Chemical Property of 5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

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Technology Process of 5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

There total 1 articles about 5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1198785-22-6
5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

Guidance literature:

Reference yield: 63.0%

: 1198785-22-6
5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

: (R)-5-(4-chloro-2-methylsulfonylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

Guidance literature:: With sodium periodate; ruthenium trichloride; In water; acetonitrile; for 18h;

Reference yield:

: 1198785-22-6
5-(4-chloro-2-methylsulfanylphenyl)-3-hydroxy-5-methyl-3-trifluoromethylhexanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)indan-2-yl ester

: 1198784-49-4
(R)-4-(4-chloro-2-methanesulfonylphenyl)-1,1,1-trifluoro-2-(5-methanesulfonyl-1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)-4-methylpentan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate / ruthenium trichloride / water; acetonitrile / 18 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 20 - 50 °C

4: potassium carbonate / methanol / 20 °C

5: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 18 h / 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 1.5 h / 70 °C

With sodium periodate; lithium aluminium tetrahydride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; ruthenium trichloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;