methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate

Base Information

• Chemical Name: methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate
• CAS No.: 1352073-02-9
• Molecular Formula: C₁₉H₁₈Cl₂O₃
• Molecular Weight: 365.256
• Mol file: 1352073-02-9.mol

Synonyms:methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate

Chemical Property of methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate

There total 5 articles about methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one (68968-12-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate (1352073-02-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ja305123v

Reference yield:

3-chlorophenylacetic acid (1878-65-5) → methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate (1352073-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.67 h / -78 °C

1.2: 5.17 h / -78 - 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

With potassium tert-butylate; sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

Methyl 4-chlorobenzoate (1126-46-1) → methyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate (1352073-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.67 h / -78 °C

1.2: 5.17 h / -78 - 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

With potassium tert-butylate; sodium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

1-bromo-3-chlorobenzene

2-(3-chlorophenyl)-1-(4-chlorophenyl)ethan-1-one

methacrylic acid methyl ester

para-chloroacetophenone

Downstream raw materials:

(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-hydroxybutan-2-yl)-3-methylpiperidin-2-one

(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-3-methylpiperidin-2-one

(S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-hydroxybutan-2-yl)-2-methylpent-4-enamide

(3S,5S,6R,8S)-8-allyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-ethyl-8-methyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium trifluoromethanesulfonate