(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

Base Information

Chemical Name:(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile
CAS No.:367944-96-5
Molecular Formula:C₁₅H₁₈N₂O
Molecular Weight:242.321
Hs Code.:

Synonyms:(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

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Technology Process of (R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

There total 3 articles about (R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 367944-95-4
(R)-2-((S)-2-Hydroxy-5-phenyl-morpholin-4-yl)-3-methyl-butyronitrile

: 367944-96-5
(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

Guidance literature:: With boron trifluoride diethyl etherate; acetic anhydride; In acetonitrile; at 20 ℃;
DOI:10.1039/b104052a

Reference yield:

: 144896-92-4,134872-85-8
(5S)-5-phenylmorpholin-2-one

: 367944-96-5
(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / HCl; Na₂SO₄ / tetrahydrofuran; dioxane / 2 h / Heating

2: 100 percent / DIBAL-H / tetrahydrofuran / -78 °C

3: 54 percent / Ac₂O; BF₃*OEt₂ / acetonitrile / 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; acetic anhydride; diisobutylaluminium hydride; sodium sulfate; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 1: Strecker reaction;
DOI:10.1039/b104052a

Reference yield:

: 367944-77-2
(R)-3-Methyl-2-((S)-2-oxo-5-phenyl-morpholin-4-yl)-butyronitrile

: 367944-96-5
(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / DIBAL-H / tetrahydrofuran / -78 °C

2: 54 percent / Ac₂O; BF₃*OEt₂ / acetonitrile / 20 °C

With boron trifluoride diethyl etherate; acetic anhydride; diisobutylaluminium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b104052a