Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

Base Information

Chemical Name:Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester
CAS No.:367944-98-7
Molecular Formula:C₁₅H₁₈N₂O₃
Molecular Weight:274.32
Hs Code.:

Synonyms:Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

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Chemical Property of Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

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Technology Process of Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

There total 4 articles about Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 367944-96-5
(R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile

: 367944-98-7
Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

Guidance literature:: (R)-3-Methyl-2-((S)-3-phenyl-2,3-dihydro-[1,4]oxazin-4-yl)-butyronitrile; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 10h;

With periodic acid; In dichloromethane; for 10h;
DOI:10.1039/b104052a

Reference yield:

: 144896-92-4,134872-85-8
(5S)-5-phenylmorpholin-2-one

: 367944-98-7
Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 79 percent / HCl; Na₂SO₄ / tetrahydrofuran; dioxane / 2 h / Heating

2.1: 100 percent / DIBAL-H / tetrahydrofuran / -78 °C

3.1: 54 percent / Ac₂O; BF₃*OEt₂ / acetonitrile / 20 °C

4.1: MCPBA / CH₂Cl₂ / 10 h

4.2: 84 percent / H₅IO₆ / CH₂Cl₂ / 10 h

With hydrogenchloride; boron trifluoride diethyl etherate; acetic anhydride; diisobutylaluminium hydride; sodium sulfate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; 1.1: Strecker reaction;
DOI:10.1039/b104052a

Reference yield:

: 367944-77-2
(R)-3-Methyl-2-((S)-2-oxo-5-phenyl-morpholin-4-yl)-butyronitrile

: 367944-98-7
Formic acid (S)-2-[((R)-1-cyano-2-methyl-propyl)-formyl-amino]-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / DIBAL-H / tetrahydrofuran / -78 °C

2.1: 54 percent / Ac₂O; BF₃*OEt₂ / acetonitrile / 20 °C

3.1: MCPBA / CH₂Cl₂ / 10 h

3.2: 84 percent / H₅IO₆ / CH₂Cl₂ / 10 h

With boron trifluoride diethyl etherate; acetic anhydride; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/b104052a