pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide

Base Information

• Chemical Name: pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide
• CAS No.: 1056640-24-4
• Molecular Formula: C₂₁H₁₉N₅O₄
• Molecular Weight: 405.413
• Mol file: 1056640-24-4.mol

Synonyms:pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide

Chemical Property of pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide

There total 2 articles about pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(Aminomethyl)pyridine (3731-51-9) + 2-Picolinic acid (98-98-6) + 3-amino-3-(2-nitrophenyl)propionic acid (5678-48-8,732242-02-3,756814-14-9) → pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide (1056640-24-4)

Guidance literature:

2-Picolinic acid; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 0.166667h; Cooling with ice;

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 18h; Cooling with ice;

2-(Aminomethyl)pyridine; 3-amino-3-(2-nitrophenyl)propionic acid;

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) + 3-(2-nitrophenyl)-3-(picolinamido)propanoic acid (1056640-28-8) → pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide (1056640-24-4)

Guidance literature:

2-(Aminomethyl)pyridine; 3-(2-nitrophenyl)-3-(picolinamido)propanoic acid; With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide; for 0.166667h; Cooling with ice;

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

DOI:10.1021/ja8047442

Reference yield: 81.0%

copper(ll) sulfate pentahydrate + pyridine-2-carboxylic acid {1-(2-nitrophenyl)-2-[(pyridine-2-ylmethyl)carbamoyl]ethyl}amide (1056640-24-4) + water (7732-18-5) → [Cu(OH2)(cage)]

Guidance literature:

With sodium hydroxide; In ethanol; Reflux;

upstream raw materials:

2-(Aminomethyl)pyridine

3-(2-nitrophenyl)-3-(picolinamido)propanoic acid

2-Picolinic acid

3-amino-3-(2-nitrophenyl)propionic acid

Downstream raw materials:

pyridine-2-carboxylic acid amide

NO₂C₆H₄CHNCOC₅H₄NCH₂CONCH₂C₅H₄NPt