[(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester
• CAS No.: 863991-39-3
• Molecular Formula: C₂₃H₃₇NO₄
• Molecular Weight: 391.551
• Mol file: 863991-39-3.mol

Synonyms:[(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

Chemical Property of [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester

There total 1 articles about [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(1R)-3-[4-(heptyloxy)phenyl]-1-(hydroxymethyl)-1-methylpropyl]carbamate (500760-46-3) → [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester (863991-39-3)

Guidance literature:

With 4-morpholinyl-N-oxide; tetrapropylammonium perruthennate; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 96.0%

[(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester (863991-39-3) → (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid (863991-38-2)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; 2,3-Dimethyl-2-butene; In tert-butyl alcohol; at 20 ℃;

DOI:10.1016/j.bmcl.2010.01.118

Reference yield: 80.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester (863991-39-3) → C27H43NO5 (1239480-61-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.bmcl.2010.01.118

upstream raw materials:

tert-butyl [(1R)-3-[4-(heptyloxy)phenyl]-1-(hydroxymethyl)-1-methylpropyl]carbamate

Downstream raw materials:

(R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid

(E)-(R)-4-tert-butoxycarbonylamino-6-(4-heptyloxy-phenyl)-4-methyl-hex-2-enoic acid ethyl ester

C₂₇H₄₃NO₅

C₂₆H₄₃NO₆S