500760-46-3

Upstream product

• 463952-35-4 [(R)-1-hydroxymethyl-3-(4-hydroxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester 
• 4282-40-0 1-Iodoheptane 
• 162358-40-9 2-(4-heptyloxyphenyl)ethyl iodide 
• 16156-51-7 heptyl methanesulfonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 463952-34-3 tert-butyl [(2R)-3-[4-(benzyloxy)phenyl]-1-(hydroxymethyl)-1-methylpropyl]carbamate 
• 241476-71-1 (2R)-2-amino-4-[4-(heptyloxy)phenyl]-2-methylbutan-1-ol 
• 500760-45-2 (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2-methyl-2,5-dihydro-pyrazine 
• 500760-51-0 (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine 

Downstream Products

• 500760-53-2 C₂₃H₄₀NO₇P 
• 1239478-11-5 (R)-4-[2-(4-heptyloxy-phenyl)-ethyl]-4-methyl-2-oxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester 
• 863991-39-3 [(R)-1-formyl-3-(4-heptyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester 
• 241476-71-1 (2R)-2-amino-4-[4-(heptyloxy)phenyl]-2-methylbutan-1-ol 
• 500760-49-6 [3-(4-heptyloxy-phenyl)-1-methyl-1-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)-propyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate

The new immunosuppressant FTY720 (fingolimod), an analog of the endogenous lipid sphingosine, induces transient lymphopenia through the sequestration of lymphocytes in secondary lymphoid organs. Phosphorylation of FTY720 by sphingosine kinase 2 (SphK2) yi

Asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives

We herein report an asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives 3, key intermediates of a novel immunomodulator, using enzymatic desymmetrization of 2-alkyl-2-tert-butoxycarbonylamino-1,3-propanediols 1a and 1b. This method makes

AMINO ACID DERIVATIVES

The present invention relates to new amino acid derivatives, process for their production, their use, in particular in transplantation, and pharmaceutical compositions containing them.

First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720

FTY720 is an immunosuppressant with a novel mode of action and is highly effective in animal models of transplantation and autoimmunity. Herein we describe the first asymmetric synthesis of chiral FTY720 analogues using the Sch?llkopf-protocol. We also describe a practical synthesis of the corresponding phosphates, which are essential tools for elucidation of FTY720's mechanism of action.