(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione
CAS No.:1400902-13-7
Molecular Formula:C₂₄H₂₃F₃N₂O₂
Molecular Weight:428.454
Hs Code.:

Synonyms:(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

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Technology Process of (E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

There total 5 articles about (E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1400902-36-4
(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

: 1400902-13-7
(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: With chloroacetic acid; In 1,4-dioxane; water; at 100 ℃; for 64h;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1400902-13-7
(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 1.5 h / 20 °C

1.3: 1.5 h / Reflux

2.1: piperidine; acetic acid / toluene / 48 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

4.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

4.2: 1.5 h / 0 °C / Reflux

5.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

With piperidine; dmap; hydrogen; sodium; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 95233-37-7,49708-81-8,1346600-43-8
(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

: 1400902-13-7
(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

1.2: 16 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

2.2: 1.5 h / 20 °C

2.3: 1.5 h / Reflux

3.1: piperidine; acetic acid / toluene / 48 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

5.2: 1.5 h / 0 °C / Reflux

6.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

With piperidine; dmap; hydrogen; sodium; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;