6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Base Information

• Chemical Name: 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• CAS No.: 1187960-58-2
• Molecular Formula: C₁₆H₂₁N₃O₄
• Molecular Weight: 319.36
• Mol file: 1187960-58-2.mol

Synonyms:6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Chemical Property of 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

There total 6 articles about 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide (1187960-57-1) → 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1187960-58-2)

Guidance literature:

With water; potassium hydroxide; In methanol; at 50 ℃; for 1h;

DOI:10.1021/ol900169f

Reference yield:

2,4-Dimethoxybenzylamine (20781-20-8) → 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1187960-58-2)

Guidance literature:

Multi-step reaction with 6 steps

1: sulfuric acid / water / 1.5 h / 85 °C

2: acetic anhydride / 1.5 h / 70 °C

3: sodium ethanolate / ethanol / 1 h / 70 °C

4: N,N-dimethyl-formamide / 4 h / 40 °C

5: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide; acetonitrile / 4.25 h / 20 - 60 °C

6: potassium hydroxide / water; methanol / 1 h / 50 °C

With sulfuric acid; tetrabutylammomium bromide; sodium ethanolate; caesium carbonate; potassium hydroxide; In methanol; ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acs.jmedchem.0c02169

Reference yield:

1-(2,4-dimethoxybenzyl)urea (296277-76-4) → 6-amino-1-[2,4-dimethoxybenzyl]-3-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1187960-58-2)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic anhydride / 1.5 h / 70 °C

2: sodium ethanolate / ethanol / 1 h / 70 °C

3: N,N-dimethyl-formamide / 4 h / 40 °C

4: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide; acetonitrile / 4.25 h / 20 - 60 °C

5: potassium hydroxide / water; methanol / 1 h / 50 °C

With tetrabutylammomium bromide; sodium ethanolate; caesium carbonate; potassium hydroxide; In methanol; ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/acs.jmedchem.0c02169

upstream raw materials:

N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

2,4-Dimethoxybenzylamine

1-(2,4-dimethoxybenzyl)urea

3-(2-cyanoacetyl)-1-[(2,4-dimethoxyphenyl)methyl]urea