N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

Base Information

Chemical Name:N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide
CAS No.:1187960-57-1
Molecular Formula:C₁₉H₂₆N₄O₄
Molecular Weight:374.44
Hs Code.:

Synonyms:N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

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Chemical Property of N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

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Technology Process of N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

There total 5 articles about N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1187960-56-0
N'-{3-[(2,4-dimethoxyphenyl)methyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

: 106-94-5
propyl bromide

: 1187960-57-1
N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

Guidance literature:: With tetrabutylammomium bromide; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 - 60 ℃; for 4h; regioselective reaction;
DOI:10.1021/ol900169f

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1187960-57-1
N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / water / 1.5 h / 85 °C

2: acetic anhydride / 1.5 h / 70 °C

3: sodium ethanolate / ethanol / 1 h / 70 °C

4: N,N-dimethyl-formamide / 4 h / 40 °C

5: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide; acetonitrile / 4.25 h / 20 - 60 °C

With sulfuric acid; tetrabutylammomium bromide; sodium ethanolate; caesium carbonate; In ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.0c02169

Reference yield:

: 296277-76-4
1-(2,4-dimethoxybenzyl)urea

: 1187960-57-1
N′-{3-[2,4-dimethoxybenzyl]-2,6-dioxo-1-propyl-1,2,3,6-tetrahydropyrimidin-4-yl}-N,N-dimethylmethanimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic anhydride / 1.5 h / 70 °C

2: sodium ethanolate / ethanol / 1 h / 70 °C

3: N,N-dimethyl-formamide / 4 h / 40 °C

4: caesium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide; acetonitrile / 4.25 h / 20 - 60 °C

With tetrabutylammomium bromide; sodium ethanolate; caesium carbonate; In ethanol; acetic anhydride; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.0c02169