1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine

Base Information

• Chemical Name: 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine
• CAS No.: 1375797-39-9
• Molecular Formula: C₂₃H₁₆F₂N₆S
• Molecular Weight: 446.483

Synonyms:1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine

Chemical Property of 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine

Chemical Property:

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Technology Process of 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine

There total 4 articles about 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)thiosemicarbazide (1375797-63-9) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine (1375797-39-9)

Guidance literature:

In ethanol; for 0.25h; Reflux;

DOI:10.1016/j.bmcl.2012.03.094

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) → 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine (1375797-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 0.25 h / 20 °C

2: acetic acid / ethanol / 1 h / Reflux

3: ethanol / 0.25 h / Reflux

With acetic acid; triethylamine; In ethanol;

DOI:10.1016/j.bmcl.2012.03.094

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 1-(2-(1H-benzo-[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)-2-(4-(4-fluorophenyl)thiazol-2-yl)hydrazine (1375797-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 0.25 h / 20 °C

2: acetic acid / ethanol / 1 h / Reflux

3: ethanol / 0.25 h / Reflux

With acetic acid; triethylamine; In ethanol;

DOI:10.1016/j.bmcl.2012.03.094

upstream raw materials:

1,2,3-Benzotriazole

1-(2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethylidene)thiosemicarbazide

2-bromo-4'-fluoroacetophenone

2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-fluorophenyl)ethanone

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