1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene

Base Information

• Chemical Name: 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene
• CAS No.: 1332524-00-1
• Molecular Formula: C₁₉H₂₀F₉NO₅
• Molecular Weight: 513.357

Synonyms:1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene

Chemical Property of 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene

There total 18 articles about 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + ethenyl (Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate (1332523-87-1) → 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene (1332524-00-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-O,O'-(3,3'-bis(naphthalen-1-ylmethyl)-5,5',6,6'-tetramethyl-1,1'-biphenyl-2,2'-diyl)-N,N-dimethylphosphoramidite; In dichloromethane; at 20 ℃; for 48h; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.125

Reference yield:

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + phenyl (Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate (1332523-84-8) → 1-[(Z)-3-phenoxyprop-1-enyl]-2-[2-(trifluoroacetylamino)-ethyl]-2,3,4-trimethoxybenzene (1332523-98-4) + 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene (1332524-00-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-O,O'-(3,3'-bis(naphthalen-1-ylmethyl)-5,5',6,6'-tetramethyl-1,1'-biphenyl-2,2'-diyl)-N,N-dimethylphosphoramidite; In dichloromethane; at 20 ℃; for 2h; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.125

Reference yield:

N-[2-(2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide (1332523-79-1) → 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene (1332524-00-1)

Guidance literature:

Multi-step reaction with 6 steps

1: N-Bromosuccinimide / tetrachloromethane / 16 h / 60 °C / Inert atmosphere

2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 24 h / Inert atmosphere; Reflux

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 18 h / Inert atmosphere; Reflux

4: sodium tetrahydroborate; hydrogen; nickel diacetate; ethylenediamine / ethanol / 40 h / 20 °C / 760.05 Torr

5: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-O,O'-(3,3'-bis(naphthalen-1-ylmethyl)-5,5',6,6'-tetramethyl-1,1'-biphenyl-2,2'-diyl)-N,N-dimethylphosphoramidite / dichloromethane / 48 h / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; N-iodo-succinimide; copper(l) iodide; (S)-O,O'-(3,3'-bis(naphthalen-1-ylmethyl)-5,5',6,6'-tetramethyl-1,1'-biphenyl-2,2'-diyl)-N,N-dimethylphosphoramidite; hydrogen; nickel diacetate; ethylenediamine; diethylamine; trifluoroacetic acid; In tetrachloromethane; ethanol; dichloromethane; acetonitrile; 3: Sonogashira coupling;

DOI:10.1016/j.tet.2011.05.125

upstream raw materials:

N-[2-(2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

N-[2-(5-bromo-2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

N-[2-(5-bromo-6-iodo-2,3,4-trimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

3-{2-bromo-3,4,5-trimethoxy-6-[2-(trifluoroacetylamino)-ethyl]phenyl}prop-2-ynol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1332524-00-1 1-[(Z)-3-(1,1,1,3,3,3-hexafluoroprop-2-yloxy)prop-1-enyl]-2-[2-(trifluoroacetylamino)ethyl]-2,3,4-trimethoxybenzene

Send

Send

Metric Ton KG G Pound L ML

Send

Send