(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

Base Information

Chemical Name:(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol
CAS No.:619315-41-2
Molecular Formula:C₂₈H₄₆O₄Se
Molecular Weight:525.631
Hs Code.:

Synonyms:(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

There total 12 articles about (1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77-76-9
2,2-dimethoxy-propane

: 619315-42-3
(R)-1-[(2R,4R)-4-((1R,2R)-2-Hydroxy-1-phenylselanyl-tetradecyl)-oxetan-2-yl]-ethane-1,2-diol

: 619315-41-2
(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

Guidance literature:: With camphor-10-sulfonic acid; at 20 ℃; for 16h;
DOI:10.1016/S0040-4020(03)01134-7

Reference yield: 45.0%

: 71098-88-9
N-phenylselanylphthalimide

: 619315-40-1
(1R,3Z,5R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]heptadec-3-ene-1,5-diol

: 619315-41-2
(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

: 619315-42-3
(R)-1-[(2R,4R)-4-((1R,2R)-2-Hydroxy-1-phenylselanyl-tetradecyl)-oxetan-2-yl]-ethane-1,2-diol

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(03)01134-7

Reference yield:

: 87604-46-4
(2R,3R)-1,2-O-isopropylidene-5-hexene-1,2,3-triol

: 619315-41-2
(1R,2R)-1-[(2R,4R)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-oxetan-2-yl]-1-phenylselanyl-tetradecan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: BuLi / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

2: 1.10 g / imidazole / tetrahydrofuran / 16 h / 20 °C

3: 68 percent / [PhCH=RuCl₂(PCy₃)2] / benzene / 64 h / Heating

4: 80 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

5: 45 percent / CSA / CH₂Cl₂ / -78 - 20 °C

With 1H-imidazole; n-butyllithium; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; Grubbs catalyst first generation; In tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1016/S0040-4020(03)01134-7