3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene

Base Information

• Chemical Name: 3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene
• CAS No.: 78620-31-2
• Molecular Formula: C₁₀H₅ClN₂O₂S
• Molecular Weight: 252.681
• Mol file: 78620-31-2.mol

Synonyms:3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene

Chemical Property of 3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene

Chemical Property:

• Melting Point: 218 - 220 °C
• PSA: 87.13000
• Density: 1.74g/cm³
• LogP: 2.89800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene

There total 2 articles about 3-chloro-2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl)benzo(b)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 3-chloro-2-hydrazinocarbonylbenzothiophene (62524-21-4) → 3-chloro-2-(2-oxo-3H-1,3,4-oxadiazole-5-yl)-benzo(b)thiophene (78620-31-2)

Guidance literature:

In dichloromethane; for 1h;

DOI:10.1021/jm00368a004

Reference yield:

3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester (21211-07-4) → 3-chloro-2-(2-oxo-3H-1,3,4-oxadiazole-5-yl)-benzo(b)thiophene (78620-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85percent aq. hydrazine / propan-2-ol / 1 h / 60 °C

2: CH₂Cl₂ / 1 h

With hydrazine hydrate; In dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00368a004

upstream raw materials:

phosgene

3-chloro-2-hydrazinocarbonylbenzothiophene

3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester

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