4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

Base Information

Chemical Name:4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline
CAS No.:1608152-84-6
Molecular Formula:C₂₄H₂₆N₂O
Molecular Weight:358.483
Hs Code.:

Synonyms:4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

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Chemical Property of 4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

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Technology Process of 4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

There total 6 articles about 4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1608152-82-4
10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

: 1608152-84-6
4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 3h; Solvent; Temperature; Reagent/catalyst;
DOI:10.1016/j.tetlet.2014.03.109

Reference yield: 47.0%

: 1539278-94-8
10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

: 1608152-84-6
4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

Guidance literature:: With borane-THF; In tetrahydrofuran; for 2.5h; Solvent; Temperature; Reagent/catalyst; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.03.109

Reference yield:

: 6-(benzyloxy)-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

: 1608152-84-6
4-(benzyloxy)-2-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-methylaniline

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 120 °C

2: borane-THF / tetrahydrofuran / 2.5 h / Reflux; Inert atmosphere

With borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.03.109