10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

Base Information

Chemical Name:10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline
CAS No.:1608152-82-4
Molecular Formula:C₂₄H₂₄N₂O
Molecular Weight:356.467
Hs Code.:

Synonyms:10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

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Chemical Property of 10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

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Technology Process of 10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

There total 5 articles about 10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1539278-94-8
10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

: 1608152-82-4
10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2014.03.109

Reference yield:

: 195986-91-5
6-hydroxy-1,2-dihydro-4H-3,1-benzoxazin-2,4-dione

: 1608152-82-4
10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.25 h

1.2: 24 h / 40 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C

3.1: N,N-dimethyl-formamide / 120 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.03.109

Reference yield:

: 1393714-32-3
6-hydroxy-1-methyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1608152-82-4
10-(benzyloxy)-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 40 °C

2: N,N-dimethyl-formamide / 120 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.03.109