10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

Base Information

Chemical Name:10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one
CAS No.:1539278-94-8
Molecular Formula:C₂₄H₂₂N₂O₂
Molecular Weight:370.451
Hs Code.:

Synonyms:10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

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Chemical Property of 10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

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Technology Process of 10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

There total 6 articles about 10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 3230-65-7
3,4-dihydroisoquinoline

: 6-(benzyloxy)-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

: 1539278-94-8
10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

Guidance literature:: In toluene; for 24h; Reflux;
DOI:10.1021/cn4002126

Reference yield:

: 394-31-0
2-amino-5-hydroxybenzoic acid

: 1539278-94-8
10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane / 2 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / methanol; water / 2 h / Reflux

4.1: oxalyl dichloride / tetrahydrofuran / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.17 h

5.2: Heating

6.1: toluene / 24 h / Reflux

With oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/cn4002126

Reference yield:

: 2-((ethoxycarbonyl)amino)-5-hydroxybenzoic acid

: 1539278-94-8
10-(benzyloxy)-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: potassium hydroxide / methanol; water / 2 h / Reflux

3.1: oxalyl dichloride / tetrahydrofuran / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.17 h

4.2: Heating

5.1: toluene / 24 h / Reflux

With oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/cn4002126