rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Base Information

Chemical Name:rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate
CAS No.:1585214-70-5
Molecular Formula:C₁₈H₂₀ClNO₄S
Molecular Weight:381.88
Hs Code.:

Synonyms:rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

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Chemical Property of rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

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Technology Process of rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

There total 2 articles about rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 106-31-0
butanoic acid anhydride

: 1585214-66-9
rac-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate

: 1585214-70-5
rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2014.01.013

Reference yield:

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

: 1585214-70-5
rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc / tetrahydrofuran / 0.5 h / Reflux

2: dmap; triethylamine / dichloromethane / 3 h / 20 °C

With dmap; triethylamine; zinc; In tetrahydrofuran; dichloromethane; 1: |Reformatsky Reaction / 1: |Reformatsky Reaction;
DOI:10.1016/j.tetasy.2014.01.013

Reference yield: 46.0%

: 1585214-70-5
rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

: 1585214-86-3
(S)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

: 1585214-82-9
(R)-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate

Guidance literature:: With Candida antarctica lipase B; ethanol; In di-isopropyl ether; for 48h; enantioselective reaction; Molecular sieve; Enzymatic reaction;
DOI:10.1016/j.tetasy.2014.01.013