(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Base Information

Chemical Name:(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate
CAS No.:1585214-74-9
Molecular Formula:C₁₈H₂₀ClNO₄S
Molecular Weight:381.88
Hs Code.:

Synonyms:(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

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Chemical Property of (R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

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Technology Process of (R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

There total 5 articles about (R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 123-20-6,24991-31-9
vinyl n-butyrate

: 1585214-66-9
rac-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate

: 1585214-74-9
(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

: 1585214-78-3
(S)-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate

Guidance literature:: With Candida antarctica lipase B; In toluene; at 20 ℃; for 19h; enantioselective reaction; Molecular sieve; Enzymatic reaction;
DOI:10.1016/j.tetasy.2014.01.013

Reference yield:

: 1585214-70-5
rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

: 1585214-74-9
(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

: 1585214-86-3
(S)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Guidance literature:: With Chiralpak IB column; In hexane; isopropyl alcohol; Resolution of racemate;
DOI:10.1016/j.tetasy.2014.01.013

Reference yield:

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

: 1585214-74-9
(R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc / tetrahydrofuran / 0.5 h / Reflux

2: Candida antarctica lipase B / toluene / 19 h / 20 °C / Molecular sieve; Enzymatic reaction

With Candida antarctica lipase B; zinc; In tetrahydrofuran; toluene; 1: |Reformatsky Reaction / 1: |Reformatsky Reaction;
DOI:10.1016/j.tetasy.2014.01.013