N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

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Chemical Name:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide
CAS No.:1101118-62-0
Molecular Formula:C₁₈H₁₆N₆O₅S
Molecular Weight:428.428
Hs Code.:

Synonyms:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

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Chemical Property of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

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Technology Process of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

There total 4 articles about N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 109-84-2
2-hydroxyethylhydrazine

: 1101120-05-1
3-formylpyrazolo[1,5-a]pyridine-5-carbonitrile

: 121-02-8
2-methyl-5-nitrobenzene-1-sulfonyl chloride

: 1101118-62-0
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: 2-hydroxyethylhydrazine; 3-formylpyrazolo[1,5-a]pyridine-5-carbonitrile; In methanol; for 1h;

2-methyl-5-nitrobenzene-1-sulfonyl chloride; With 2,6-dimethylpyridine; In methanol; for 1.5h;
DOI:10.1016/j.bmc.2011.11.031

Reference yield:

: 1101120-03-9
pyrazolo[1,5-a]pyridine-5-carboxamide

: 1101118-62-0
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 18.5 h / 0 - 20 °C

1.2: 1 h / 0 °C / pH 10

2.1: methanol / 2 h

2.2: 3 h

With trichlorophosphate; In methanol; 1.1: Vilsmeier Formylation;

Reference yield:

: 1101120-00-6
3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

: 1101118-62-0
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; water / 16 h / Heating / reflux

1.2: 0 °C / pH 2

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h

2.2: 2 h / 0 °C

3.1: trichlorophosphate / 18.5 h / 0 - 20 °C

3.2: 1 h / 0 °C / pH 10

4.1: methanol / 2 h

4.2: 3 h

With sulfuric acid; water; 1,1'-carbonyldiimidazole; trichlorophosphate; In tetrahydrofuran; methanol; 3.1: Vilsmeier Formylation;