3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Base Information

Chemical Name:3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS No.:1323405-54-4
Molecular Formula:C₂₉H₃₅N₃O₄
Molecular Weight:489.615
Hs Code.:

Synonyms:3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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Chemical Property of 3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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Technology Process of 3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

There total 13 articles about 3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1323410-28-1
methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate

: 1323405-54-4
3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 1323290-64-7
methyl 4,5-diamino-5-oxo-pentanoate hydrochloride

: 1323405-54-4
3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 16 h / 60 °C / Inert atmosphere

4.1: acetonitrile / 20 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928

Reference yield:

: 603-80-5
3-hydroxy 2-methylbenzoic acid

: 1323405-54-4
3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 17 h / 65 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 1 h / 25 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / ethyl acetate / 2 h / 65 °C / Inert atmosphere; Irradiation

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide; water / 15 h / 15 °C / Inert atmosphere

5.2: 0.17 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / acetonitrile / 16 h / 60 °C / Inert atmosphere

7.1: acetonitrile / 20 °C / Inert atmosphere

8.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.9b01928