1323410-28-1

Basic information

• Product Name: methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate
• Synonyms: methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate
• CAS NO: 1323410-28-1
• Molecular Weight: 521.657
• Mol File: 1323410-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate(1323410-28-1)
• EPA Substance Registry System: methyl 5-amino-4-(4-(4-((4-isopropylpiperidin-1-yl)methyl)benzyloxy)-1-oxoisoindolin-2-yl)-5-oxopentanoate(1323410-28-1)

Safety Data

• Hazardous Substances Data: 1323410-28-1(Hazardous Substances Data)

Upstream product

• 1499-55-4 DL-glutamic acid-5-methyl ester 
• 112159-16-7 2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid 
• 617-65-2 Glutamic acid 
• 359629-73-5 3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-benzoic acid methyl ester 
• 55289-05-9 methyl 3-hydroxy-2-methylbenzoate 
• 603-80-5 3-hydroxy 2-methylbenzoic acid 
• 1323290-64-7 methyl 4,5-diamino-5-oxo-pentanoate hydrochloride 
• 1323407-17-5 2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester 
• 1323407-16-4 4-carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid methyl ester 
• 19678-58-1 4-Isopropylpiperidine 

Downstream Products

• 1323405-54-4 3-(4-((4-((4-isopropylpiperidin-1-yl)methyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 

Relevant articles and documents

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to therapy (i.e., are refractory), and although the mean survival of MM patients has more than doubled in recent years, most patients will eventually relapse. To address this need, we explored the potential of novel cereblon E3 ligase modulators (CELMoDs) for the treatment of patients with relapsed or refractory multiple myeloma (RRMM). We found that optimization beyond potency of degradation, including degradation efficiency and kinetics, could provide efficacy in a lenalidomide-resistant setting. Guided by both phenotypic and protein degradation data, we describe a series of CELMoDs for the treatment of RRMM, culminating in the discovery of CC-92480, a novel protein degrader and the first CELMoD to enter clinical development that was specifically designed for efficient and rapid protein degradation kinetics.