(4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

Base Information

Chemical Name:(4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone
CAS No.:88668-81-9
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:(4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

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Chemical Property of (4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

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Technology Process of (4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

There total 12 articles about (4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 88635-94-3
(R)-1-((S)-4-Isopropyl-2-oxo-oxazolidin-3-yl)-2-methyl-3-phenyl-propane-1,3-dione

: 88668-81-9
(4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: With zinc borohydride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja00316a077

Reference yield: 89.0%

: 77877-19-1,165657-81-8
N-isopropyl oxazolidinone

: 100-52-7
benzaldehyde

: 77877-25-9
(4S)-3-((2S,3S)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl)-4-(1-methylethyl)-2-oxazolidinone

: 77877-25-9,79618-02-3,88668-81-9,104758-28-3,131347-12-1
3-(3-Hydroxy-2-methyl-3-phenylpropionyl)-4-(S)-isopropyl-2-oxazolidone

Guidance literature:: N-isopropyl oxazolidinone; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.666667h; Inert atmosphere;

benzaldehyde; diastereoselective reaction; Further stages;
DOI:10.1021/acs.orglett.9b02848

Reference yield:

: 77877-19-1,165657-81-8
N-isopropyl oxazolidinone

: 88668-81-9
(4S)-3-<(2R,3R)-3-hydroxy-2-methyl-1-oxo-3-phenylpropyl>-4-(1-methylethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropylamide

2: tetrahydrofuran / -78 °C

3: 95 percent / zinc borohydride / CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

With zinc borohydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00316a077