[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

Base Information

Chemical Name:[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester
CAS No.:248953-93-7
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

[4-(2-<i>tert</i>-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

Synonyms:[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

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Chemical Property of [4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

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Technology Process of [4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

There total 3 articles about [4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.2%

: 77119-85-8
N-(tert-butoxycarbonyl)-D-phenylalaninal

: 3254-97-5
4-aminophenyl acetic acid benzyl ester

: 248953-93-7
[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; acetic acid; at 0 ℃; for 1h;
DOI:10.1248/cpb.47.1141

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 248953-93-7
[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85.9 percent / BOP; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: 70.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C

3: 46.2 percent / NaBH₃CN / methanol; acetic acid / 1 h / 0 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1: Condensation / 2: Reduction / 3: reductive amination;
DOI:10.1248/cpb.47.1141

Reference yield:

: 115186-33-9
(R)-tert-butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 248953-93-7
[4-(2-tert-butoxycarbonylamino-3-phenyl-propylamino)-phenyl]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C

2: 46.2 percent / NaBH₃CN / methanol; acetic acid / 1 h / 0 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; acetic acid; 1: Reduction / 2: reductive amination;
DOI:10.1248/cpb.47.1141