17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

Base Information

Chemical Name:17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol
CAS No.:300351-06-8
Molecular Formula:C₂₈H₄₁N₅O₅
Molecular Weight:527.664
Hs Code.:

Synonyms:17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

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Chemical Property of 17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

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Technology Process of 17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

There total 4 articles about 17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 28166-06-5
4-fluoro-3-nitrophenylazide

: 300350-92-9
17α-aminomethyl-3,3-(dimethoxy)-5α-androstan-17β-ol

: 300351-06-8
17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: With triethylamine; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 846-46-8
androstanedione

: 300351-06-8
17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / pTsOH*H₂O / 1 h / 40 °C

2: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

3: 72 percent / 25 percent aq. NH₄OH; AcOH / aq. ethanol / 72 h / 40 °C

4: 91 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

With ammonium hydroxide; potassium tert-butylate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9

Reference yield:

: 3591-19-3
3,3-(dimethoxy)-5α-androstan-17-one

: 300351-06-8
17α-[(N-4-azido-2-nitrophenyl)aminomethyl]-3,3-dimethoxy-5α-androstan-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / potassium t-butoxide / dimethylformamide / 1 h / 22 °C

2: 72 percent / 25 percent aq. NH₄OH; AcOH / aq. ethanol / 72 h / 40 °C

3: 91 percent / Et₃N / tetrahydrofuran; ethanol; diethyl ether

With ammonium hydroxide; potassium tert-butylate; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(00)00106-9