2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

Base Information

Chemical Name:2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide
CAS No.:86410-85-7
Molecular Formula:C₂₉H₄₅F₃N₂O₂
Molecular Weight:510.684
Hs Code.:

Synonyms:2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

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Chemical Property of 2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

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Technology Process of 2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

There total 6 articles about 2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 123-75-1
pyrrolidine

: 69876-92-2
4-(2,2,2-trifluoro-N-hexadecylacetamido)benzoyl chloride

: 86410-85-7
2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

Guidance literature:: With pyridine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00364a010

Reference yield:

: 55986-43-1
4-(n-hexadecylamino)benzoic acid

: 86410-85-7
2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1,2-dimethoxy-ethane; CH₂Cl₂ / 20 - 25 °C / Heating

2: thionyl chloride / CH₂Cl₂ / 4 h / Heating

3: 90 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; thionyl chloride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00364a010

Reference yield:

: 55791-63-4
ethyl 4-(hexadecylamino)benzoate

: 86410-85-7
2,2,2-Trifluoro-N-hexadecyl-N-[4-(pyrrolidine-1-carbonyl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / aq. ethanol / 6 h / Heating

2: thionyl chloride / 1,2-dimethoxy-ethane; CH₂Cl₂ / 20 - 25 °C / Heating

3: thionyl chloride / CH₂Cl₂ / 4 h / Heating

4: 90 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; potassium hydroxide; thionyl chloride; In 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1021/jm00364a010