5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine

Base Information

• Chemical Name: 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine
• CAS No.: 1384570-85-7
• Molecular Formula: C₃₆H₄₄N₂O₇SeSi
• Molecular Weight: 723.8
• Mol file: 1384570-85-7.mol

Synonyms:5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine

Chemical Property of 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine

There total 8 articles about 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 2′-O-tert-butyldimethylsilyl-2-selenouridine → 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine (1384570-85-7)

Guidance literature:

With pyridine; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.3987/COM-15-13349

Reference yield:

5'-O-dimetoxytrityl-2-selenouridine (1384570-83-5) + tert-butyldimethylsilyl chloride (18162-48-6) → 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine (1384570-85-7) + C36H44N2O7SeSi (1384570-88-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1093/nar/gks010

Reference yield:

C27H54N2O5SSi3 (127838-69-1) → 5′-O-(4,4′-dimetoxytrityl)-2′-O-tert-butyldimethylsilyl-2-selenouridine (1384570-85-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; selenium / ethanol / 4 h / 0 - 60 °C / Inert atmosphere

3.1: trifluoroacetic acid / water / 6 h / 20 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

4.3: 2 h / 20 - 60 °C / Inert atmosphere

5.1: pyridine hydrogenfluoride; pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

6.1: pyridine / 2 h / 20 °C / Inert atmosphere

With pyridine; selenium; sodium tetrahydroborate; pyridine hydrogenfluoride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.3987/COM-15-13349

upstream raw materials:

C₃₁H₃₂N₂O₇S

5’-O-dimetoxytrityl-2-thiouridine

5'-O-dimetoxytrityl-2-selenouridine

tert-butyldimethylsilyl chloride