2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide

Base Information

• Chemical Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide
• CAS No.: 78458-11-4
• Molecular Formula: C₂₃H₂₄ClNO₆
• Molecular Weight: 445.9
• Mol file: 78458-11-4.mol

Synonyms:2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide

Chemical Property of 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide

There total 2 articles about 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide (78458-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 0.75 h / Ambient temperature

2: CHCl₃ / 24 h / Ambient temperature

In chloroform;

DOI:10.1002/jps.2600831112

Reference yield:

1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole (78436-46-1) + diethylene glycol (111-46-6) → 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide (78458-11-4)

Guidance literature:

In chloroform; for 24h; Yield given; Ambient temperature;

DOI:10.1002/jps.2600831112

Reference yield:

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide (78458-11-4) → [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) + diethylene glycol (111-46-6)

Guidance literature:

With isotonic phosphate buffer; at 32 ℃; chemical and enzymatic stability; other temperature and reagents, other pH; other olygoethylene derivatives as substrates;

DOI:10.1002/jps.2600831112

upstream raw materials:

1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole

diethylene glycol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Downstream raw materials:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

diethylene glycol

2-[4-Amino-3-bromo-5-(N-ethyl-cyclohexylaminomethyl)benzoyloxy]-2'-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-diethyloxide