2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Base Information

Chemical Name:2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine
CAS No.:628316-81-4
Molecular Formula:C₄₄H₄₉N₅O₁₂
Molecular Weight:839.899
Hs Code.:

Synonyms:2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Suppliers and Price of 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

There total 3 articles about 2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 593-51-1
methylamine hydrochloride

: 628316-74-5
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'-O-α-D-glucopyranosyl-6-chloro-9-β-D-ribofuranosidopurine

: 628316-81-4
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Guidance literature:: With triethylamine; In ethanol; dichloromethane; at 60 ℃;
DOI:10.1021/jm030883f

Reference yield:

: 87-42-3
6-chloropurine

: 628316-81-4
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / DBU; TMSOTf / acetonitrile / 1 h / 60 °C

2: 67 percent / Et₃N / CH₂Cl₂; ethanol / 60 °C

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; acetonitrile; 1: modified Vorbrueggen condensation;
DOI:10.1021/jm030883f

Reference yield:

: 197644-83-0
1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside

: 628316-81-4
2',3'',4''-tri-O-acetyl-2'',5',6''-tri-O-benzyl-3'O-α-D-glucopyranosyl-6-methylamino-9-β-D-ribofuranosylpurine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / DBU; TMSOTf / acetonitrile / 1 h / 60 °C

2: 67 percent / Et₃N / CH₂Cl₂; ethanol / 60 °C

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; acetonitrile; 1: modified Vorbrueggen condensation;
DOI:10.1021/jm030883f