tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate

Base Information

• Chemical Name: tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate
• CAS No.: 1163720-74-8
• Molecular Formula: C₁₈H₁₇FN₄O₄
• Molecular Weight: 372.356

Synonyms:tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate

Chemical Property of tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate

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Technology Process of tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate

There total 8 articles about tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2,3-diaminopyridine (1163720-66-8) + Glyoxilic acid (298-12-4) → tert-butyl 2-fluoro-4-(2-oxo-1,2-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate (1163720-73-7) + tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate (1163720-74-8)

Guidance literature:

In methanol; Large scale;

Reference yield: 69.0%

glyoxylic acid ethyl ester (924-44-7) + 4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2,3-diaminopyridine (1163720-66-8) → tert-butyl 2-fluoro-4-(2-oxo-1,2-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate (1163720-73-7) + tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate (1163720-74-8)

Guidance literature:

In ethanol; toluene; at 20 ℃; for 3h; Molecular sieve;

DOI:10.1021/jm100383b

Reference yield: 69.0%

→ tert-butyl 2-fluoro-4-(2-oxo-1,2-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate (1163720-73-7) + tert-butyl (2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)carbamate (1163720-74-8)

Guidance literature:

upstream raw materials:

glyoxylic acid ethyl ester

4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2,3-diaminopyridine

Glyoxilic acid

4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-3-nitro-2-aminopyridine

Downstream raw materials:

tert-butyl 4-(3-chloropyrido[2,3-b]pyrazin-8-yloxy)-2-fluorophenylcarbamate

8-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one

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