2,2-Difluoroethanol

Base Information

• Chemical Name: 2,2-Difluoroethanol
• CAS No.: 359-13-7
• Molecular Formula: C2H4F2O
• Molecular Weight: 82.05
• Hs Code.: 29055900
• Mol file: 359-13-7.mol

Synonyms:Difluoroethanol;

Chemical Property of 2,2-Difluoroethanol

Chemical Property:

• Vapor Pressure: 25.1mmHg at 25°C
• Melting Point: -28 °C
• Refractive Index: 1.338
• Boiling Point: 95.5 °C at 760 mmHg
• PKA: 13.00±0.10(Predicted)
• Flash Point: 0.4 °C
• PSA: 20.23000
• Density: 1.166 g/cm³
• LogP: 0.24380
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: soluble in chloroform, ethanol.

Purity/Quality:

99% ^*data from raw suppliers

2,2-Difluoroethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-20/21/22-36/37/38
• Safety Statements: 16-36/37/39-45-60-37-33-26-7

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.

Technology Process of 2,2-Difluoroethanol

There total 24 articles about 2,2-Difluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-1,1-difluoroethane (359-07-9) → difluoroethanol (359-13-7)

Guidance literature:

2-bromo-1,1-difluoroethane; With sodium acetate; potassium iodide; In N,N-dimethyl-formamide; at 125 ℃; for 20h;

With sodium hydroxide; In methanol; N,N-dimethyl-formamide; at 65 ℃; for 2h; Product distribution / selectivity;

Reference yield: 99.55%

2,2-difluoroethyl acetate (1550-44-3) → difluoroethanol (359-13-7)

Guidance literature:

With ethanol; sodium ethanolate; at 20 ℃; for 1.5h; Temperature;

Reference yield: 94.0%

2,2-difluoroethyl formate (1137875-58-1) → difluoroethanol (359-13-7)

Guidance literature:

In methanol; at 60 - 100 ℃; for 5.5h;

upstream raw materials:

difluoroacetyl chloride

2-bromo-1,1-difluoroethane

Difluoroacetic acid

2,2-difluoroethyl 2,2,2-trifluoroethanesulfonate

Downstream raw materials:

glycolic Acid

tris(2,2-difluoroethyl) phosphate

1-chloro-2,2-difluoroethane

Dichlorodifluoromethane

Refernces

• 1、 Reifenrath, William G.,Roche, Edward B.,Al-Turk, Walid A.,Johnson, Howard L.. "Synthesis and Biological Activity of Fluoroalkylamine Derivatives of Narcotic Analgesics". . p. 985 - 990. Retrieved 1980.
• 2、 Schrems, Otto,Oberhoffer, Helmut M.,Luck, Werner A. P.. "Hydrogen Bonding in Low-Temperature Matrices: 1. Proton Donor Abilities of Fluoroalcohols. Comparative Infrared Studies of ROH...O(CH3)2 Complex Formation in the Gas Phase, in CCl4 Solution, and in Solid Argon". . p. 4335 - 4342. Retrieved 1984.
• 3、 Dub, Pavel A.,Batrice, Rami J.,Gordon, John C.,Scott, Brian L.,Minko, Yury,Schmidt, Jurgen G.,Williams, Robert F.. "Engineering Catalysts for Selective Ester Hydrogenation". . p. 415 - 442. Retrieved 2020/03/04.
• 4、 -. "SYNTHESIS OF FLUORO HEMIACETALS VIA TRANSITION METAL-CATALYZED FLUORO ESTER AND CARBOXAMIDE HYDROGENATION". Paragraph 0237-0238; 0259-0260. . Retrieved 2020/11/24.