1550-44-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2,2-Difluoroethyl Acetate is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique fluorinated structure contributes to the development of new drugs with improved properties, such as enhanced bioavailability and targeted activity.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,2-Difluoroethyl Acetate serves as a crucial building block for the creation of novel agrochemicals. Its incorporation into these compounds can lead to more effective and environmentally friendly pesticides and herbicides.
Safety Precautions:
Due to its potentially harmful effects, including skin, eye, and respiratory irritation, handling 2,2-Difluoroethyl Acetate requires appropriate protective measures to ensure the safety of those working with the compound.

Upstream product

• 1426-06-8 difluoromethyl alcohol 
• 75-36-5 acetyl chloride 
• 359-07-9 2-bromo-1,1-difluoroethane 
• 127-08-2 potassium acetate 
• 338-65-8 1-chloro-2,2-difluoroethane 
• 127-09-3 sodium acetate 

Downstream Products

• 359-13-7 difluoroethanol 

Relevant academic research and scientific papers

Synthetic method of 2,2-difluoroethyl acetate

The invention discloses a synthetic method of 2,2-difluoroethyl acetate, and relates to the technical field of battery electrolyte additives, and the synthetic method comprises the following steps: taking 2, 2-difluoroethanol and acetyl chloride, and under the action of an acid capturing agent, carrying out acylation reaction to obtain the 2,2-difluoroethyl acetate. Compared with the prior art, the synthesis method of the 2,2-difluoroethyl acetate has the advantages that the reaction process is milder and safer, and the product yield and the product purity in the production process are maximized by controlling the reaction conditions in each stage; the product yield is further improved by reasonably controlling the use amount of the reaction raw materials and the reaction process, the yield reaches 99.10% or above, the method is suitable for industrial production, and the purity reaches 99.5% or above.

Method for synthesizing 2,2-difluoroethanol from R142

The invention provides a method for synthesizing 2,2-difluoroethanol from R142. The method comprises the following steps: reacting the R142 with alkali metal formate or alkali metal acetate to preparean intermediate; and reacting the intermediate with alcohol under the catalysis of an oxide carrier loaded metal element catalyst to prepare 2,2-difluoroethanol. In the oxide carrier loaded metal element catalyst, the oxide carrier is aluminum oxide, magnesium oxide or zirconium dioxide, and the metal element is one or a combination of two or more of Mg, Ca, Sr, Ba, Na, K, Rb, Cs, La, Nd, Y and Ce. The oxide carrier loaded metal elements are used as the catalyst, so that the catalyst can be recycled, no alkaline waste liquid is generated, and the catalyst is environment-friendly and low in cost; and the reaction temperature is proper, side reactions are few, and the yield and purity of the obtained target product are high.

NONAQUEOUS ELECTROLYTE COMPOSITIONS COMPRISING SILYL OXALATES

Disclosed herein are electrolyte compositions comprising a fluorinated solvent, at least one silyl oxalate represented by the formulas RR′Si(C2O4), wherein R and R′ are each the same or different from each other and independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, or C6-C10 aryl radical, optionally comprising at least one substituent selected from halogen, hydroxyl, alkoxy, carbonyl, and carboxyl groups; and LiPF6. Also disclosed herein are electrolyte compositions comprising a fluorinated solvent and a lithium oxalato phosphate salt represented by the formula LiPF(6-2q)(C2O4)q, wherein q is 1, 2 or 3; wherein the oxalato phosphate salt comprises at least a portion that is derived from at least one silyl oxalate as defined herein. The electrolyte compositions are useful in electrochemical cells, such as lithium ion batteries.

Difluoroethanol synthesis method using 2,2-difluoro-1-chloroethane as raw material

The invention relates to a difluoroethanol synthesis method using 2,2-difluoro-1-chloroethane as a raw material, and aims to solve the problems that in the prior art, the reaction conditions are strict, and the product yield and purity are low. According to the method, 2,2-difluoro-1-chloroethane and metal acetate are taken as the raw materials, 2,2-difluoro-1-chloroethane and metal acetate carryout reactions in a solvent to generate difluoroethyl acetate, and then under the action of a sulfuric acid supported silicon dioxide catalyst, difluoroethyl acetate and alcohols carry out transesterification to generate difluoroethanol. The method has the advantages of mild reaction conditions, high product yield, and high purity. The catalyst can be repeatedly used. The method is suitable for industrial production.

NONAQUEOUS ELECTROLYTE COMPOSITIONS COMPRISING FLUORINATED SULFONES

Disclosed herein are electrolyte compositions comprising a fluorinated solvent, a fluorinated sulfone, at least one component selected from a borate salt, and/or an oxalate salt, and/or a fluorinated cyclic carbonate, and at least one electrolyte salt. The fluorinated solvent may be a fluorinated acyclic carboxylic acid ester, a fluorinated acyclic carbonate, a fluorinated acyclic ether, or combinations thereof. The electrolyte compositions are useful in electrochemical cells, such as lithium ion batteries.

PROCESS FOR PREPARING 2,2-DIFLUOROETHANOL

Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base.

FLUORINE-CONTAINING ESTERS AND METHODS OF PREPARATION THEREOF

A method for preparing fluorine-containing carboxylic acid esters is described in which a salt of a carboxylic acid is reacted with a fluorinated alkyl halide. The fluorine-containing carboxylic acid esters prepared by the method disclosed herein are particularly useful as electrolyte solvents for electrochemical cells, such as a lithium ion battery, where a high purity solvent is desired.

PROCESS FOR THE PREPARATION OF FLUORINE CONTAINING ORGANIC COMPOUND

Process for the preparation of a fluorine containing organic molecule, which process comprises the steps of a) preparation of a compound of the formula (I) wherein R1, R2 and R3 are independently hydrogen, fluor or an optionally fluorinated hydrocarbon group by feeding a compound of the formula (II) wherein R1, R2 and R3 are defined as above, and hydrogen bromide into a reaction zone, thereby producing a reaction mixture containing the compound of formula (II) and hydrogen bromide and irradiating said reaction mixture with UV light, and b) substituting the bromo atom in the compound of the formula (I) with another functional group to obtain the fluorine containing organic molecule. The invention allows also in particular for obtaining substantially anhydrous fluoroalcohols. The preparation of alcohols analogous to the bromides of formula (I) from the corresponding esters is also disclosed.