3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole
• CAS No.: 70187-22-3
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.28
• Mol file: 70187-22-3.mol

Synonyms:3-Mppt;3-(4-Methoxyphenyl)-4-phenyl-4H-1,2,4-triazole;3-p-Methoxyphenyl-4-phenyl-1,2,4-triazol;

Chemical Property of 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole

Chemical Property:

• Vapor Pressure: 5.27E-08mmHg at 25°C
• Boiling Point: 441.8°C at 760 mmHg
• Flash Point: 221°C
• PSA: 39.94000
• Density: 1.17g/cm³
• LogP: 2.94290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole

There total 7 articles about 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C15H15N3OS (342631-66-7) → 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole (70187-22-3)

Guidance literature:

With copper(ll) bromide; In dimethyl sulfoxide; at 80 ℃; for 2h;

DOI:10.1021/acs.joc.5b00956

Reference yield:

4-Phenyl-3-thiosemicarbazide (5351-69-9) → 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole (70187-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: copper(ll) bromide / dimethyl sulfoxide / 2 h / 80 °C

With copper(ll) bromide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/acs.joc.5b00956

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 3-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole (70187-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: copper(ll) bromide / dimethyl sulfoxide / 2 h / 80 °C

With copper(ll) bromide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/acs.joc.5b00956

upstream raw materials:

4-methoxy-benzoic acid N'-formyl-hydrazide

aniline

methyl 4-methoxybenzoate

4-methoxybenzoic acid hydrazide