tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

Base Information

• Chemical Name: tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide
• CAS No.: 1233249-89-2
• Molecular Formula: Br*C₂₄H₄₂O₂P
• Molecular Weight: 473.474
• Mol file: 1233249-89-2.mol

Synonyms:tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

Chemical Property of tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

There total 1 articles about tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tributylphosphine (998-40-3) + 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester (108052-76-2) → tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide (1233249-89-2)

Guidance literature:

In toluene; at 60 ℃; for 1.16667h;

DOI:10.1248/cpb.c13-00980

Reference yield: 58.0%

tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide (1233249-89-2) + 1-chloro-isoquinoline-4-carboxylic acid methyl ester (37497-86-2) → methyl 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylate (1233249-90-5)

Guidance literature:

tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide; 1-chloro-isoquinoline-4-carboxylic acid methyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -30 - 50 ℃; for 2.25h;

With sodium carbonate; In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1248/cpb.c13-00980

Reference yield:

tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide (1233249-89-2) → 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid (1233248-29-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

1.2: 2 h / 60 °C

1.3: pH 5

2.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

3.2: 3 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

4.2: pH 5 / Cooling with ice

5.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / Cooling with ice

5.2: 1 h / Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 20 °C / Cooling with ice

6.2: pH 5

With oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

upstream raw materials:

tributylphosphine

4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

Downstream raw materials:

methyl 1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylate

2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

1-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]isoquinoline-4-carboxylic acid

4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid