2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-29-7
Molecular Formula:C₂₇H₂₃ClN₂O₃
Molecular Weight:458.944
Hs Code.:

Synonyms:2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

Chemical Property:

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Technology Process of 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

There total 12 articles about 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-94-9
methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

: 1233248-29-7
2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

Guidance literature:: methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2.5h; Cooling with ice;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1233248-29-7
2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

1.2: 2 h / 60 °C

1.3: pH 5

2.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

3.2: 3 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

4.2: pH 5 / Cooling with ice

5.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / Cooling with ice

5.2: 1 h / Cooling with ice

6.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 20 °C / Cooling with ice

6.2: pH 5

With oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1233248-29-7
2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 1.17 h / 60 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

2.2: 2 h / 60 °C

2.3: pH 5

3.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

3.2: pH 5

4.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

4.2: 3 h / Cooling with ice

5.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

5.2: pH 5 / Cooling with ice

6.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / Cooling with ice

6.2: 1 h / Cooling with ice

7.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 20 °C / Cooling with ice

7.2: pH 5

With oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;