(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

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Chemical Name:(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one
CAS No.:250355-75-0
Molecular Formula:C₄₆H₆₃NO₉Si₂
Molecular Weight:830.179
Hs Code.:

(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

Synonyms:(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

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Chemical Property of (2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

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Technology Process of (2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

There total 13 articles about (2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₂₁H₃₃NO₆Si₂

: 250355-71-6
{4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-yl}-acetaldehyde

: 250355-75-0
(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

: (2R,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane;
DOI:10.1021/ja011604l

Reference yield:

: 250355-74-9
(R)-3-Hydroxy-3-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-propionic acid

: 250355-75-0
(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / TMSOTf

With trimethylsilyl trifluoromethanesulfonate;
DOI:10.1021/ol990830l

Reference yield:

: 250355-70-5
acetic acid 4-(tert-butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-yl ester

: 250355-75-0
(2S,6R)-2-{(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / ZnCl₂

2: 61 percent / TMSOTf

With trimethylsilyl trifluoromethanesulfonate; zinc(II) chloride;
DOI:10.1021/ol990830l