5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine
CAS No.:1338923-37-7
Molecular Formula:C₄₃H₅₁FN₅O₈PS
Molecular Weight:847.945
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

There total 10 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338923-34-4
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1338923-37-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 1338923-31-1
4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

: 1338923-37-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 h

2: tin(II) chloride dihdyrate / diethyl ether; dichloromethane / Cooling with ice

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With pyridine; tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 1338923-32-2
5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

: 1338923-37-7
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / diethyl ether; dichloromethane / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2011.08.035