5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine
CAS No.:1338923-32-2
Molecular Formula:C₃₃H₃₂FN₃O₇S
Molecular Weight:633.697
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Suppliers and Price of 5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

There total 7 articles about 5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338923-36-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

: 1338923-32-2
5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Guidance literature:: With triethylamine tris(hydrogen fluoride); for 8h; Neat (no solvent);
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 1338923-31-1
4-deoxo-3,4-dehydro-4-(2-cyanoethylthio)-5-fluorouridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1338923-32-2
5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Guidance literature:: With pyridine; for 5h;
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 1338923-33-3
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

: 1338923-32-2
5'-O-(4,4'-dimethoxytrityl)-4-deoxo-3,4-dehydro-4-(2-cyanoethylthio-)-5-fluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 20 °C

2: triethylamine tris(hydrogen fluoride) / 8 h / Neat (no solvent)

With triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1016/j.bmc.2011.08.035