5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

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Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine
CAS No.:1338923-33-3
Molecular Formula:C₄₄H₅₈FN₅O₇Si₂
Molecular Weight:844.143
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: 5'-O-(4,4'-dimethoxytrityl)-2',3'-O-bis(tert-butyldimethylsilyl)-5-fluorouridine

: 1338923-33-3
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

Guidance literature:: 1,2,4-Triazole; With triethylamine; trichlorophosphate; In acetonitrile; at 0 ℃; for 0.166667h;

5'-O-(4,4'-dimethoxytrityl)-2',3'-O-bis(tert-butyldimethylsilyl)-5-fluorouridine; With pyridine; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1338923-33-3
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine; trichlorophosphate / acetonitrile / 0.17 h / 0 °C

2.2: 0 - 20 °C

With 1H-imidazole; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.08.035

Reference yield:

: 157770-09-7
5’-O-4,4'-dimethoxytrityl-5-fluorouridine

: 1338923-33-3
5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-t-butyldimethylsilyl-5-fluoro-4-deoxo-3,4-dehydro-4-(1,2,4-triazol-1-yl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine; trichlorophosphate / acetonitrile / 0.17 h / 0 °C

2.2: 0 - 20 °C

With 1H-imidazole; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.08.035