(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

Base Information

Chemical Name:(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate
CAS No.:1357261-78-9
Molecular Formula:C₂₄H₂₉FN₂O₇Si
Molecular Weight:504.587
Hs Code.:

Synonyms:(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

Suppliers and Price of (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

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Technology Process of (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

There total 15 articles about (1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 99-34-3
3,5-dinitrobenzoic acid

: 1357261-76-7
(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

: 1357261-78-9
(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1055/s-0031-1289863

Reference yield: 62.0%

: 1357261-80-3
C₁₇H₂₇FO₂Si

: 99-33-2
3,5-dinitrobenoyl chloride

: 1357261-78-9
(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1039/d0cc02621b

Reference yield:

: 1357261-90-5
C₁₁H₁₆O₆

: 1357261-78-9
(1S,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentyl 3,5-dinitrobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: novozyme 435 / 0.17 h / 20 °C / Enzymatic reaction

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: lithium triethylborohydride / tetrahydrofuran / 1 h / 20 °C

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; novozyme 435; di-isopropyl azodicarboxylate; lithium triethylborohydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 6.1: Mitsunobu reaction;
DOI:10.1055/s-0031-1289863