(R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate
• CAS No.: 1255701-85-9
• Molecular Formula: C₃₀H₃₃N₅O₄
• Molecular Weight: 527.623
• Mol file: 1255701-85-9.mol

Synonyms:(R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate

Chemical Property of (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate

There total 6 articles about (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (958245-18-6) + (R)-tert-butyl 8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (1255701-86-0) → (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (1255701-85-9)

Guidance literature:

With ethanol; caesium carbonate; acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium; In 1,2-dimethoxyethane; at 100 ℃; for 0.75h; Microwave vial; Inert atmosphere;

Reference yield:

2,6-dichloro-5-pyridylmethyl chloride (41789-37-1) → (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (1255701-85-9)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

3: dichloromethane / 20 °C

4: ethanol; caesium carbonate / acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium / 1,2-dimethoxyethane / 0.75 h / 100 °C / Microwave vial; Inert atmosphere

With ethanol; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-butyl 8-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (1255701-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: ethanol; caesium carbonate / acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium / 1,2-dimethoxyethane / 0.75 h / 100 °C / Microwave vial; Inert atmosphere

With ethanol; caesium carbonate; acetato(2'-di-tert-butylphosphino-1,1'-biphenyl-2-yl)-palladium; In 1,2-dimethoxyethane; dichloromethane;

upstream raw materials:

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

(R)-tert-butyl 8-chloro-2-phenyl-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate

2,6-dichloro-5-pyridylmethyl chloride

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine