1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

Base Information

Chemical Name:1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate
CAS No.:1200437-93-9
Molecular Formula:C₂₃H₂₆N₂O₅
Molecular Weight:410.47
Hs Code.:

Synonyms:1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

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Chemical Property of 1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

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Technology Process of 1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

There total 1 articles about 1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1200437-92-8
C₁₈H₁₈N₂O₃

: 1200437-93-9
1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.3762/bjoc.5.43

Reference yield: 97.0%

: 1200437-93-9
1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

: 74-88-4
methyl iodide

: 1-benzyl 3-tert-butyl rac-(cis)-5-methyl-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

Guidance literature:: 1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -78 - -55 ℃; for 17h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.3762/bjoc.5.43

Reference yield: 79.0%

: 1200437-93-9
1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

: 100-39-0
benzyl bromide

: 1-benzyl 3-tert-butyl rac-(cis)-5-benzyl-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate

Guidance literature:: 1-benzyl 3-tert-butyl rac-4-oxo-2-phenyl-dihydropyrimidine-1,3(2H,4H)-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -78 - -55 ℃; for 17h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.3762/bjoc.5.43