N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

Base Information

Chemical Name:N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide
CAS No.:864961-79-5
Molecular Formula:C₂₂H₂₀F₂N₂O₅S₂
Molecular Weight:494.54
Hs Code.:

Synonyms:N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

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Chemical Property of N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

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Technology Process of N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

There total 10 articles about N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864961-74-0
5-acetyl-2-amino-thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-amide

: 403-43-0
4-fluorobenzoyl chloride

: 864961-79-5
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; for 1.5h;

Reference yield:

: 864961-69-3
3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-carboxylic acid methyl ester

: 864961-79-5
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / 2 h / 90 - 100 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

4.2: 0.17 h

5.1: water; trifluoroacetic acid / 0.17 h

5.2: pH 11

6.1: sodium hydroxide / tetrahydrofuran; water; ethyl acetate / 1.5 h / 20 °C

With methanol; sodium hydroxide; N-Bromosuccinimide; diphenyl phosphoryl azide; water; triethylamine; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 864961-70-6
(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

: 864961-79-5
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-4-fluoro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

2.2: 0.17 h

3.1: water; trifluoroacetic acid / 0.17 h

3.2: pH 11

4.1: sodium hydroxide / tetrahydrofuran; water; ethyl acetate / 1.5 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; water; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;