(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

Base Information

Chemical Name:(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester
CAS No.:864961-70-6
Molecular Formula:C₁₈H₂₃FN₂O₅S₂
Molecular Weight:430.521
Hs Code.:

Synonyms:(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

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Chemical Property of (3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

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Technology Process of (3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

There total 6 articles about (3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864961-71-7
C₁₄H₁₄FNO₅S₂

: 75-65-0
tert-butyl alcohol

: 864961-70-6
(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 90 - 100 ℃; for 2h;

Reference yield:

: 131326-99-3
2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanone

: 864961-70-6
(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2: palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 50 °C

3: triethylamine / tetrahydrofuran / 1.33 h / 0 - 20 °C

4: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

5: diphenyl phosphoryl azide; triethylamine / 2 h / 90 - 100 °C

With methanol; sodium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; water; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 133962-00-2
1-(4-fluorophenyl)-2-<(N-benzyl-N-methyl)amino>ethanol

: 864961-70-6
(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 50 °C

2: triethylamine / tetrahydrofuran / 1.33 h / 0 - 20 °C

3: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

4: diphenyl phosphoryl azide; triethylamine / 2 h / 90 - 100 °C

With methanol; sodium hydroxide; diphenyl phosphoryl azide; water; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethyl acetate;