2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

Base Information

Chemical Name:2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole
CAS No.:108797-08-6
Molecular Formula:C₁₉H₂₁N₃
Molecular Weight:291.396
Hs Code.:

Synonyms:2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

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Chemical Property of 2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

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Technology Process of 2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

There total 4 articles about 2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18450-24-3
ethyl N-methylindole-2-carboxylate

: 108797-08-6
2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / Et₃SiH / trifluoroacetic acid / 2 h / Heating

2: 1.) AlCl₃ / 1.) ethylene dichloride, RT, 30 min, 2.) ethylene dichloride, reflux, 6 h

3: 53 percent / H₂ / 10percent Pd/C / ethanol / 72 h / 2585.7 Torr / Ambient temperature

4: 1.) trimethylaluminum / 1.) toluene, RT, 1 h, 2.) toluene, reflux, 45 min

With triethylsilane; aluminium trichloride; hydrogen; trimethylaluminum; palladium on activated charcoal; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm00392a005

Reference yield:

: 97608-35-0
ethyl 1-methyl-2,3-dihydro-1H-indole-2-carboxylate

: 108797-08-6
2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) AlCl₃ / 1.) ethylene dichloride, RT, 30 min, 2.) ethylene dichloride, reflux, 6 h

2: 53 percent / H₂ / 10percent Pd/C / ethanol / 72 h / 2585.7 Torr / Ambient temperature

3: 1.) trimethylaluminum / 1.) toluene, RT, 1 h, 2.) toluene, reflux, 45 min

With aluminium trichloride; hydrogen; trimethylaluminum; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00392a005

Reference yield:

: 108796-94-7
5-Benzoyl-1-methyl-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

: 108797-08-6
2-(4,5-dihydro-1H-imidazol-2-yl)-2,3-dihydro-1-methyl-5-(phenylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / H₂ / 10percent Pd/C / ethanol / 72 h / 2585.7 Torr / Ambient temperature

2: 1.) trimethylaluminum / 1.) toluene, RT, 1 h, 2.) toluene, reflux, 45 min

With hydrogen; trimethylaluminum; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00392a005