(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1623785-62-5
Molecular Formula:C₂₀H₂₅BrN₂O₆S
Molecular Weight:501.398
Hs Code.:

Synonyms:(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1623785-56-7
(±)-2-(3-bromo-4,5-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 7778-42-9
sulphamoyl chloride

: 1623785-62-5
(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N,N-dimethyl acetamide; In toluene; at 0 - 25 ℃; for 2h;
DOI:10.1002/cmdc.201402025

Reference yield:

: 1602588-43-1
(+/-)-7-methoxy-3-methyl-6-(triisopropylsilyloxy)-1,2,3,4-tetrahydro-isoquinoline

: 1623785-62-5
(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h

3: N,N-dimethyl acetamide / toluene / 2 h / 0 - 25 °C

With N,N-dimethyl acetamide; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402025

Reference yield:

: 1026729-08-7
1-bromo-5-(bromomethyl)-2,3-dimethoxybenzene

: 1623785-62-5
(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h

3: N,N-dimethyl acetamide / toluene / 2 h / 0 - 25 °C

With N,N-dimethyl acetamide; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402025