Sulfamoyl chloride

Base Information

• Chemical Name: Sulfamoyl chloride
• CAS No.: 7778-42-9
• Molecular Formula: ClH2NO2S
• Molecular Weight: 115.54
• Hs Code.: 2935009090
• European Community (EC) Number: 805-900-4
• NSC Number: 158265
• UNII: 65MMZ8TWQ5
• DSSTox Substance ID: DTXSID30228396
• Nikkaji Number: J283.218F
• Wikidata: Q27263894
• Mol file: 7778-42-9.mol

Synonyms:Sulfamoyl chloride;7778-42-9;CHLOROSULFONAMIDE;CHLOROSULFAMIC ACID;Amidosulfonyl chloride;Aminosulfonyl chloride;Sulfamyl chloride;Chloroimidosulfuric acid;UNII-65MMZ8TWQ5;65MMZ8TWQ5;MFCD11519990;NSC-158265;sulfamic chloride;chlorosulfonarnide;Sulphamoyl chloride;chlorosulfonyl amine;sulfamoy l chloride;NSC 158265;Amidosulphonyl chloride;ClSO2NH2;H2NSO2Cl;NH2SO2Cl;AMY9077;DTXSID30228396;QAHVHSLSRLSVGS-UHFFFAOYSA-N;NSC158265;AKOS015900919;SY006415;CS-0008551;FT-0674695;EN300-30440;A26268;Q27263894

Chemical Property of Sulfamoyl chloride

Chemical Property:

• Melting Point: 40-41 °C
• Refractive Index: 1.509
• Boiling Point: 100-105 °C(Press: 4 Torr)
• PKA: 6.82±0.60(Predicted)
• PSA: 68.54000
• Density: 1.788 g/cm³
• LogP: 1.20980
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 114.9494772
• Heavy Atom Count: 5
• Complexity: 95.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

SulfamoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: NS(=O)(=O)Cl
• Uses: Sulfamoyl chloride is Used for the preparation of substituted glycoside sulfamates as anticonvulsant agents for the treatment of epilepsy.

Technology Process of Sulfamoyl chloride

There total 9 articles about Sulfamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

isocyanate de chlorosulfonyle (1189-71-5) → sulphamoyl chloride (7778-42-9)

Guidance literature:

With formic acid; at 0 - 20 ℃; for 1h;

Reference yield: 100.0%

formic acid (64-18-6) + isocyanate de chlorosulfonyle (1189-71-5) → sulphamoyl chloride (7778-42-9)

Guidance literature:

In toluene; at 23 ℃; for 10h; Inert atmosphere;

Reference yield: 94.0%

→ sulphamoyl chloride (7778-42-9)

Guidance literature:

upstream raw materials:

isocyanate de chlorosulfonyle

water

formic acid

sodium phenylsulfamate

Downstream raw materials:

2-ethyl-3-O-sulfamoyl-17β-(2-(OTBDPS)ethyl) 17-deoxy estrone

(S)-1-(3,4,5-Trimethoxy-phenylsulfamoyl)-piperidine-2-carboxylic acid (4-phenyl-butyl)-amide

Sulfamic acid 2-(2-methylphenoxy)ethyl ester

2-(3-Methoxyphenoxy)ethanol sulfamate (ester)

Refernces

• 1、 Zhao, Yang,Wang, Xiao-Qing,Yu, Yan-Jiang,Zhou, Yong-Gui. "Kinetic Resolution of [2.2]Paracyclophane-Derived Cyclic N-Sulfonylimines via Palladium-Catalyzed Addition of Arylboronic Acids". . p. 1262 - 1272. Retrieved 2021.
• 2、 Burke, Eileen G.,Gold, Brian,Hoang, Trish T.,Raines, Ronald T.,Schomaker, Jennifer M.. "Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs". . p. 8029 - 8037. Retrieved 2017.
• 3、 Brawn, Ryan A.,Zhu, Kaicheng,Panek, James S.. "Rhodium(II)-catalyzed alkyne amination of homopropargylic sulfamate esters: Stereoselective synthesis of functionalized norcaradienes by arene cyclopropanation". . p. 74 - 77. Retrieved 2014.
• 4、 Kurzawa, Timon,Kerste, Eric,Nikodemiak, Paul,Bothe, Daniel,Harms, Klaus,Koert, Ulrich. "Stereoselective Synthesis of the β-Amino Acid Moiety of Fijiolide A". . p. 1261 - 1267. Retrieved 2019.
• 5、 Leitz, Dominik,Stierstorfer, Karin,Morgenstern, Yvonne,Zischka, Florian,Kornath, Andreas J.. "The Influence of the Counterions [AsF6]– and [GeF6]2– on the Structure of the [ClSO2NH3]+ Cation". . p. 483 - 488. Retrieved 2018.
• 6、 De Ruysscher, Dries,Pang, Luping,Lenders, Stijn M.G.,Cappoen, Davie,Cos, Paul,Rozenski, Jef,Strelkov, Sergei V.,Weeks, Stephen D.,Van Aerschot, Arthur. "Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors". . . Retrieved 2020/12/02.