pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

Base Information

Chemical Name:pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]
CAS No.:1335299-49-4
Molecular Formula:C₂₀H₁₄F₃N₇O₂
Molecular Weight:441.372
Hs Code.:

Synonyms:pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

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Chemical Property of pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

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Technology Process of pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

There total 3 articles about pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 753-90-2
trifluoroethylamine

: 1335299-50-7
3-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-pyrazine-2-carboxylic acid

: 1335299-49-4
pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

Guidance literature:: 3-(2-phenyl-imidazo[1,2-a]pyrimidin-7-ylcarbamoyl)-pyrazine-2-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

trifluoroethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1335299-49-4
pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / 5 h / Reflux

1.2: 0.25 h

2.1: dmap / N,N-dimethyl-formamide / 78 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 591227-12-2
2-phenylimidazo[1,2-a]pyrimidin-7-amine

: 1335299-49-4
pyrazine-2,3-dicarboxylic acid 2-[(2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide] 3-[(2,2,2-trifluoro-ethyl)-amide]

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / N,N-dimethyl-formamide / 78 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;